Tumbler - Rapid Optimizationįigure 2: Kinetics graph demonstrating the rapid optimization in antibody affinity Tumbler provides, over 10x greater binding activity in both cyno and human targets. Not only does Tumbler provide a single affinity-improved version, you will also receive an entire panel of antibodies with varying paratopes for you to analyze and select the best version. Tumbler provides an optimal affinity maturation tool that can increasing your antibody candidate’s binding as much as two log KD, or 130x improved. Antibody humanization with Tumbler far exceeds chimeric CDR grafting.įigure 1: Antibody lead candidate results from Tumbler that show the candidate is demonstrating greater than 90% human structural characteristics while retaining or improving antibody affinity. Your antibody is ‘tumbled’ through our proprietary technology, producing an antibody candidate that is identical to human antibody structure and behavior. What can Antibody Optimization do for Your Antibodies? 1. Tumbler can also be used to retrofit antibodies to cross to a new version of the original target providing an avenue to repurpose drug and lead candidates, creating a cost-effective route of drug discovery. Delivering fully-human therapeutic-ready antibodies improved for affinity, potency, cross-reactivity, specificity, and biophysical attributes. Tumbler is designed to enhance the therapeutic or diagnostic performance of any antibody candidate, regardless of format. Tumbler provides simultaneous, multi-factor antibody engineering and optimization for antibody candidates discovered from our antibody libraries, or from your own development.
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